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Description
Cleaved Caspase-3 (Asp175) Recombinant Rabbit mAb (S-1406-409)Product Specification Host Rabbit Antigen Cleaved Caspase 3 (Asp175) Synonyms Caspase 3; CASP 3; Apopain; Cysteine protease CPP32 (CPP 32); Protein Yama; SREBP cleavage activity 1 (SCA 1); CPP32; CASP3 Immunogen Synthetic Peptide Location Cytoplasm Accession P42574 Clone Number S 1406 409 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | Cleaved Caspase-3 (Asp175) |
| Synonyms | Caspase-3; CASP-3; Apopain; Cysteine protease CPP32 (CPP-32); Protein Yama; SREBP cleavage activity 1 (SCA-1); CPP32; CASP3 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P42574 |
| Clone Number | S-1406-409 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu, Rt |
| ICC | 1:500 | Hu |
Background
Cleaved Caspase-3 (Asp175) is the ~17/19 kDa proteolytically activated form of human caspase-3 that, once cleaved after Asp175-Ser176 during apoptosis, loses its N-terminal pro-domain, assembles into active hetero-tetramers (p17/p12) and relentlessly hydrolyzes Asp-x bonds in >100 cytoplasmic, nuclear and cytoskeletal substrates—such as PARP, ICAD, ROCK1 and gelsolin—thereby dismantling cellular architecture, inactivating DNA repair, triggering chromatin condensation, membrane blebbing and phosphatidyl-serine exposure, and thus serving as the pivotal executioner caspase whose appearance, detected by the widely used “Asp175” neo-epitope antibody, is universally recognized as an irreversible biochemical signature of cells committed to programmed cell death.
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