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Description
Human Annexin A1 , His TagProduct Specification Species Human Synonyms Annexin I, Annexin 1, Calpactin II, Calpactin 2, Chromobindin 9 Accession P04083 Amino Acid Sequence Protein sequence(P04083, Ala2 Asn346 with C 10*His)
Product Specification
| Species | Human |
| Synonyms | Annexin I, Annexin-1, Calpactin II, Calpactin-2, Chromobindin-9 |
| Accession | P04083 |
| Amino Acid Sequence |
Protein sequence(P04083, Ala2-Asn346 with C-10*His)
|
| Expression System | E.coli |
| Molecular Weight | Theoretical: 40.4kDa Actual: 40kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage |
12 months from date of receipt, -20 ℃ to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Annexin A1 belongs to the annexin family of Ca2+-dependent phospholipid-binding proteins. Annexin A1 has important opposing properties during innate and adaptive immune responses: it inhibits innate immune cells and promotes T-cell activation. The activation of T cells results in the release of annexin A1 and the expression of its receptor. This pathway seems to fine-tune the strength of TCR signalling. Higher expression of annexin A1 during pathological conditions could increase the strength of TCR signalling through the mitogen-activated protein kinase signalling pathway, thereby causing a state of hyperactivation of T cells. Annexin A1 has also been of interest for use as a potential anticancer drug. Upon induction by modified NSAIDS and other potent anti-inflammatory drugs, annexin A1 inhibits the NF-κB signal transduction pathway, which is exploited by cancerous cells to proliferate and avoid apoptosis. ANXA1 inhibits the activation of NF-κB by binding to the p65 subunit.
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