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Description
Human CD19, His tagProduct Specification Species Human Synonyms B lymphocyte surface antigen B4; Differentiation antigen CD19; T cell surface antigen Leu 12 Accession P15391 Amino Acid Sequence Protein sequence(P15391, Arg19 Thr287, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12 |
| Accession | P15391 |
| Amino Acid Sequence | Protein sequence(P15391, Arg19-Thr287, with C-10*His) |
| Expression System | HEK293 |
| Molecular Weight | Theoretical: 31.5kDa Actual: 45-53kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage |
12 months from date of receipt, -20 ℃ to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
B-lymphocyte antigen CD19 is a transmembrane protein that in humans is encoded by the gene CD19, This gene encodes a member of the immunoglobulin gene superfamily. In humans, CD19 is expressed in all B lineage cells. Contrary to some early doubts, human plasma cells do express CD19, as confirmed by others. CD19 plays two major roles in human B cells: on the one hand, it acts as an adaptor protein to recruit cytoplasmic signaling proteins to the membrane; on the other, it works within the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Due to its presence on all B cells, it is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for leukemia immunotherapies.
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